Antidepressants Normalize the Default Mode Network in Patients With Dysthymia | Zendy

Jonathan Posner | Zendy; David J. Hellerstein | Zendy; Inbal Gat | Zendy; Anna E. Mechling | Zendy; Kristin Klahr | Zendy; Zhishun Wang | Zendy; Patrick J. McGrath | Zendy; Jonathan W. Stewart | Zendy; Bradley S. Peterson | Zendy

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Antidepressants Normalize the Default Mode Network in Patients With Dysthymia

Author(s) -

Jonathan Posner,

David J. Hellerstein,

Inbal Gat,

Anna E. Mechling,

Kristin Klahr,

Zhishun Wang,

Patrick J. McGrath,

Jonathan W. Stewart,

Bradley S. Peterson

Publication year - 2013

Publication title -

jama psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.531

H-Index - 365

eISSN - 2168-6238

pISSN - 2168-622X

DOI - 10.1001/jamapsychiatry.2013.455

Subject(s) - default mode network , resting state fmri , duloxetine , functional magnetic resonance imaging , major depressive disorder , placebo , psychology , medicine , functional connectivity , magnetic resonance imaging , antidepressant , neuroscience , psychiatry , mood , hippocampus , pathology , alternative medicine , radiology

The default mode network (DMN) is a collection of brain regions that reliably deactivate during goal-directed behaviors and is more active during a baseline, or so-called resting, condition. Coherence of neural activity, or functional connectivity, within the brain's DMN is increased in major depressive disorder relative to healthy control (HC) subjects; however, whether similar abnormalities are present in persons with dysthymic disorder (DD) is unknown. Moreover, the effect of antidepressant medications on DMN connectivity in patients with DD is also unknown.

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