Open AccessFunctional Magnetic Resonance Imaging of Impaired Sensory Prediction in Schizophrenia
Author(s) -
Sukhwinder S. Shergill,
Thomas P. White,
Daniel Joyce,
Paul M. Bays,
Daniel M. Wolpert,
Chris Frith
Publication year - 2013
Publication title -
jama psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.531
H-Index - 365
eISSN - 2168-6238
pISSN - 2168-622X
DOI - 10.1001/jamapsychiatry.2013.2974
Subject(s) - functional magnetic resonance imaging , psychology , schizophrenia (object oriented programming) , somatosensory system , sensory system , neuroimaging , sensation , neuroscience , psychosis , sensory processing , audiology , magnetic resonance imaging , efference copy , sense of agency , medicine , psychiatry , radiology
Forward models predict the sensory consequences of planned actions and permit discrimination of self- and non-self-elicited sensation; their impairment in schizophrenia is implied by an abnormality in behavioral force-matching and the flawed agency judgments characteristic of positive symptoms, including auditory hallucinations and delusions of control.
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