Open AccessSupport for the N -Methyl-D-Aspartate Receptor Hypofunction Hypothesis of Schizophrenia From Exome Sequencing in Multiplex Families
Author(s) -
Andrew E. Timms,
Michael O. Dorschner,
Jeremy Wechsler,
Kyu Yeong Choi,
Robert Kirkwood,
Santhosh Girirajan,
Carl Baker,
Evan E. Eichler,
Olena Korvatska,
Katherine W. Roche,
Marshall S. Horwitz,
Debby W. Tsuang
Publication year - 2013
Publication title -
jama psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.531
H-Index - 365
eISSN - 2168-6238
pISSN - 2168-622X
DOI - 10.1001/jamapsychiatry.2013.1195
Subject(s) - genetics , exome sequencing , biology , copy number variation , comparative genomic hybridization , exome , frameshift mutation , gene , mutation , genome
Schizophrenia is a complex genetic disorder demonstrating considerable heritability. Genetic studies have implicated many different genes and pathways, but much of the genetic liability remains unaccounted for. Investigation of genetic forms of schizophrenia will lead to a better understanding of the underlying molecular pathways, which will then enable targeted approaches for disease prevention and treatment.
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