Open AccessEffect of Nonintervention vs Oral Ibuprofen in Patent Ductus Arteriosus in Preterm Infants
Author(s) -
Se In Sung,
Myung Hee Lee,
So Yoon Ahn,
Yun Sil Chang,
Won Soon Park
Publication year - 2020
Publication title -
jama pediatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.004
H-Index - 183
eISSN - 2168-6211
pISSN - 2168-6203
DOI - 10.1001/jamapediatrics.2020.1447
Subject(s) - medicine , bronchopulmonary dysplasia , ibuprofen , ductus arteriosus , gestational age , randomized controlled trial , placebo , pediatrics , randomization , gestation , anesthesia , pregnancy , genetics , alternative medicine , pathology , pharmacology , biology
Persistent patent ductus arteriosus (PDA) in preterm infants is associated with increased mortality and respiratory morbidities, including bronchopulmonary dysplasia (BPD). Despite recent increasing use of noninterventional approaches, no study to our knowledge has yet directly compared the nonintervention vs pharmacologic treatment for mediating PDA closure for decreasing mortality and preventing BPD.
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