Effectiveness of Intrapleural Tissue Plasminogen Activator and Dornase Alfa vs Tissue Plasminogen Activator Alone in Children with Pleural Empyema | Zendy

Michael H. Livingston | Zendy; Sanjay Mahant | Zendy; Bairbre Connolly | Zendy; Ian MacLusky | Zendy; Sophie Laberge | Zendy; Lucia Giglia | Zendy; Connie Yang | Zendy; Ashley Roberts | Zendy; Anna C. Shawyer | Zendy; Mary E. Brindle | Zendy; Simon Parsons | Zendy; Cristina Stoian | Zendy; J. Mark Walton | Zendy; Kevin E. Thorpe | Zendy; Yang Chen | Zendy; Fei Zuo | Zendy; Muhammad Mamdani | Zendy; Carol Chan | Zendy; Desmond Loong | Zendy; Wanrudee Isaranuwatchai | Zendy; Félix Ratjen | Zendy; Eyal Cohen | Zendy

Open Access

Effectiveness of Intrapleural Tissue Plasminogen Activator and Dornase Alfa vs Tissue Plasminogen Activator Alone in Children with Pleural Empyema

Author(s) -

Michael H. Livingston,

Sanjay Mahant,

Bairbre Connolly,

Ian MacLusky,

Sophie Laberge,

Lucia Giglia,

Connie Yang,

Ashley Roberts,

Anna C. Shawyer,

Mary E. Brindle,

Simon Parsons,

Cristina Stoian,

J. Mark Walton,

Kevin E. Thorpe,

Yang Chen,

Fei Zuo,

Muhammad Mamdani,

Carol Chan,

Desmond Loong,

Wanrudee Isaranuwatchai,

Félix Ratjen,

Eyal Cohen

Publication year - 2020

Publication title -

jama pediatrics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.004

H-Index - 183

eISSN - 2168-6211

pISSN - 2168-6203

DOI - 10.1001/jamapediatrics.2019.5863

Subject(s) - medicine , empyema , tissue plasminogen activator , plasminogen activator , pleural empyema , activator (genetics) , surgery , receptor

Clinical guidelines recommend that children with pleural empyema be treated with chest tube insertion and intrapleural fibrinolytics. The addition of dornase alfa (DNase) has been reported to improve outcomes in adults but remains unproven in children.

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