Association Between Early Postoperative Acetaminophen Exposure and Acute Kidney Injury in Pediatric Patients Undergoing Cardiac Surgery | Zendy

Sara L. Van Driest | Zendy; Edmund H. Jooste | Zendy; Yaping Shi | Zendy; Leena Choi | Zendy; Leon Darghosian | Zendy; Kevin D. Hill | Zendy; Andrew Smith | Zendy; Prince J. Kannankeril | Zendy; Dan M. Roden | Zendy; Lorraine B. Ware | Zendy

Open Access

Association Between Early Postoperative Acetaminophen Exposure and Acute Kidney Injury in Pediatric Patients Undergoing Cardiac Surgery

Author(s) -

Sara L. Van Driest,

Edmund H. Jooste,

Yaping Shi,

Leena Choi,

Leon Darghosian,

Kevin D. Hill,

Andrew Smith,

Prince J. Kannankeril,

Dan M. Roden,

Lorraine B. Ware

Publication year - 2018

Publication title -

jama pediatrics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.004

H-Index - 183

eISSN - 2168-6211

pISSN - 2168-6203

DOI - 10.1001/jamapediatrics.2018.0614

Subject(s) - medicine , acute kidney injury , interquartile range , retrospective cohort study , extracorporeal membrane oxygenation , cardiac surgery , kidney disease , cardiopulmonary bypass , creatinine , cohort , cohort study , renal replacement therapy , surgery , anesthesia

Acute kidney injury (AKI) is a common and serious complication for pediatric cardiac surgery patients associated with increased morbidity, mortality, and length of stay. Current strategies focus on risk reduction and early identification because there are no known preventive or therapeutic agents. Cardiac surgery and cardiopulmonary bypass lyse erythrocytes, releasing free hemoglobin and contributing to oxidative injury. Acetaminophen may prevent AKI by reducing the oxidation state of free hemoglobin.

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