Epidemiologic Association BetweenFUT2Secretor Status and Severe Rotavirus Gastroenteritis in Children in the United States | Zendy

Daniel C. Payne | Zendy; Rebecca L. Currier | Zendy; Mary Allen Staat | Zendy; Leila C. Sahni | Zendy; Rangaraj Selvarangan | Zendy; Natasha Halasa | Zendy; Janet A. Englund | Zendy; Geoffrey A. Weinberg | Zendy; Julie A. Boom | Zendy; Peter G. Szilagyi | Zendy; Eileen J. Klein | Zendy; James D. Chappell | Zendy; Christopher J. Harrison | Zendy; Barbara Davidson | Zendy; Slavica Mijatovic-Rustempasic | Zendy; Mary D. Moffatt | Zendy; Monica McNeal | Zendy; Mary E. Wikswo | Zendy; Michael D. Bowen | Zendy; Ardythe L. Morrow | Zendy; Umesh D. Parashar | Zendy

Open Access

Epidemiologic Association BetweenFUT2Secretor Status and Severe Rotavirus Gastroenteritis in Children in the United States

Author(s) -

Daniel C. Payne,

Rebecca L. Currier,

Mary Allen Staat,

Leila C. Sahni,

Rangaraj Selvarangan,

Natasha Halasa,

Janet A. Englund,

Geoffrey A. Weinberg,

Julie A. Boom,

Peter G. Szilagyi,

Eileen J. Klein,

James D. Chappell,

Christopher J. Harrison,

Barbara Davidson,

Slavica Mijatovic-Rustempasic,

Mary D. Moffatt,

Monica McNeal,

Mary E. Wikswo,

Michael D. Bowen,

Ardythe L. Morrow,

Umesh D. Parashar

Publication year - 2015

Publication title -

jama pediatrics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.004

H-Index - 183

eISSN - 2168-6211

pISSN - 2168-6203

DOI - 10.1001/jamapediatrics.2015.2002

Subject(s) - medicine , rotavirus , association (psychology) , rotavirus infections , pediatrics , immunology , virology , virus , philosophy , epistemology

A genetic polymorphism affecting FUT2 secretor status in approximately one-quarter of humans of European descent affects the expression of histo-blood group antigens on the mucosal epithelia of human respiratory, genitourinary, and digestive tracts. These histo-blood group antigens serve as host receptor sites necessary for attachment and infection of some pathogens, including norovirus.

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