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A Living Systematic Review of Nebulized Hypertonic Saline for Acute Bronchiolitis in Infants
Author(s) -
Robert G. Badgett,
Mohinder R. Vindhyal,
Jason T. Stirnaman,
C. Michael Gibson,
Rim Halaby
Publication year - 2015
Publication title -
jama pediatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.004
H-Index - 183
eISSN - 2168-6211
pISSN - 2168-6203
DOI - 10.1001/jamapediatrics.2015.0681
Subject(s) - medicine , hypertonic saline , bronchiolitis , acute bronchiolitis , intensive care medicine , pediatrics , anesthesia , respiratory system
Results | The LTL (expressed in the telomere repeat copy number to the single gene copy number ratio) remained unchanged during and after the OC intake. In contrast, the LTL doubled while taking PioFluMet and returned to baseline after the PioFluMet intake was stopped (Figure). The LTL changes across treatment groups during 18 months related inversely to fasting insulinemia, body fat fraction by dual energy x-ray absorptiometry, and visceral and hepatic adiposity by magnetic resonance imaging (all r values were between −0.53 and −0.57; all P values were between 0.002 and 0.007). The ratio of circulating neutrophils to lymphocytes was first similar in treatment groups and remained similar in and between groups across 24 months. Noteworthy adverse effects were not encountered in either treatment group.4

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