A Proposal to Redefine Close Surgical Margins in Squamous Cell Carcinoma of the Oral Tongue | Zendy

Daniella K. Zai | Zendy; Jocelyn Migliacci | Zendy; Bin Xu | Zendy; Nora Katabi | Zendy; Pablo H. Montero | Zendy; Ian Ganly | Zendy; Jatin P. Shah | Zendy; Richard J. Wong | Zendy; Ronald Ghossein | Zendy; Snehal G. Patel | Zendy

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A Proposal to Redefine Close Surgical Margins in Squamous Cell Carcinoma of the Oral Tongue

Author(s) -

Daniella K. Zai,

Jocelyn Migliacci,

Bin Xu,

Nora Katabi,

Pablo H. Montero,

Ian Ganly,

Jatin P. Shah,

Richard J. Wong,

Ronald Ghossein,

Snehal G. Patel

Publication year - 2017

Publication title -

jama otolaryngology–head and neck surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.571

H-Index - 128

eISSN - 2168-619X

pISSN - 2168-6181

DOI - 10.1001/jamaoto.2016.4238

Subject(s) - margin (machine learning) , medicine , tongue , surgical margin , receiver operating characteristic , proportional hazards model , retrospective cohort study , resection margin , cutoff , basal cell , primary tumor , clinical endpoint , surgery , cancer , radiology , resection , pathology , metastasis , physics , randomized controlled trial , quantum mechanics , machine learning , computer science

Resection of the primary tumor with negative margins is the gold standard treatment for squamous cell carcinoma of the oral tongue (SCCOT). A microscopically positive surgical margin is clearly associated with a higher risk for local recurrence, whereas a negative margin has traditionally been defined as greater than 5.0 mm clearance from the tumor, with lesser margins arbitrarily designated as close. The precise cutoff at which the risk for local recurrence with a close margin approximates that of a microscopically positive margin remains unclear.

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