Open AccessAssociation of Circulating Tumor Cell Status With Benefit of Radiotherapy and Survival in Early-Stage Breast Cancer
Author(s) -
Chelain R. Goodman,
Brandon-Luke L. Seagle,
Thomas W. P. Friedl,
Brigitte Rack,
Krisztián Látó,
Visnja Fink,
Massimo Cristofanilli,
Eric D. Donnelly,
Wolfgang Janni,
Shohreh Shahabi,
Jonathan Strauss
Publication year - 2018
Publication title -
jama oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.846
H-Index - 99
eISSN - 2374-2445
pISSN - 2374-2437
DOI - 10.1001/jamaoncol.2018.0163
Subject(s) - medicine , interquartile range , breast cancer , oncology , cancer , surrogate endpoint , cohort , radiation therapy , stage (stratigraphy) , retrospective cohort study , clinical trial , cohort study , biology , paleontology
Treatment with RT was associated with longer LRFS, DFS, and OS in patients with early-stage breast cancer and detectable CTCs. These results are hypothesis generating; a prospective trial evaluating CTC-based management for RT after breast-conserving surgery in women with early-stage breast cancer is warranted.
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