Mismatch Repair Deficiency, Microsatellite Instability, and Survival | Zendy

Elizabeth Smyth | Zendy; Andrew Wotherspoon | Zendy; Clare Peckitt | Zendy; David González | Zendy; Sanna Hulkki-Wilson | Zendy; Zakaria Eltahir | Zendy; Matteo Fassan | Zendy; Massimo Rugge | Zendy; Nicola Valeri | Zendy; Alicia Okines | Zendy; Madeleine Hewish | Zendy; William Allum | Zendy; Sally Stenning | Zendy; Matthew Nankivell | Zendy; Ruth E. Langley | Zendy; David Cunningham | Zendy

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Mismatch Repair Deficiency, Microsatellite Instability, and Survival

Author(s) -

Elizabeth Smyth,

Andrew Wotherspoon,

Clare Peckitt,

David González,

Sanna Hulkki-Wilson,

Zakaria Eltahir,

Matteo Fassan,

Massimo Rugge,

Nicola Valeri,

Alicia Okines,

Madeleine Hewish,

William Allum,

Sally Stenning,

Matthew Nankivell,

Ruth E. Langley,

David Cunningham

Publication year - 2017

Publication title -

jama oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.846

H-Index - 99

eISSN - 2374-2445

pISSN - 2374-2437

DOI - 10.1001/jamaoncol.2016.6762

Subject(s) - microsatellite instability , medicine , epirubicin , oncology , perioperative , cancer , chemotherapy , dna mismatch repair , colorectal cancer , gastroenterology , surgery , allele , breast cancer , microsatellite , biochemistry , chemistry , gene

Mismatch repair (MMR) deficiency (MMRD) and microsatellite instability (MSI) are prognostic for survival in many cancers and for resistance to fluoropyrimidines in early colon cancer. However, the effect of MMRD and MSI in curatively resected gastric cancer treated with perioperative chemotherapy is unknown.

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