Open AccessLongitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer Disease
Author(s) -
Alexis Moscoso,
Michel J. Grothe,
Nicholas J. Ashton,
Thomas K. Karikari,
Juan Lantero Rodrı́guez,
Anniina Snellman,
Marc SuárezCalvet,
Kaj Blennow,
Henrik Zetterberg,
Michael Schöll,
Michael W. Weiner,
Paul Aisen,
Ronald C. Petersen,
Clifford R. Jack,
William J. Jagust,
John Q. Trojanowki,
Arthur W. Toga,
Laurel Beckett,
Robert C. Green,
Andrew J. Saykin,
John C. Morris,
Leslie M. Shaw,
Zaven S. Khachaturian,
Greg Sorensen,
Marı́a C. Carrillo,
Lew Kuller,
Marc Raichle,
Steven M. Paul,
Peter Davies,
Howard Fillit,
Franz Hefti,
David M. Holtzman,
Marek-Marsel Mesulam,
William Z. Potter,
Peter J. Snyder,
Veronika Logovinsky,
Tom Montine,
Gustavo Jiménez,
Michael Donohue,
Devon Gessert,
Kelly Harless,
Jennifer Salazar,
Yuliana Cabrera,
Sarah Walter,
Lindsey Hergesheimer,
Danielle Harvey,
Matt A. Bernstein,
Nick C. Fox,
Paul M. Thompson,
Norbert Schuff,
Charles DeCarli,
Bret Borowski,
Jeff Gunter,
Matthew L. Senjem,
Prashanthi Vemuri,
David T. Jones,
Kejal Kantarci,
Chad Ward,
Robert A. Koeppe,
Norm Foster,
Eric M. Reiman,
Kewei Chen,
Chester A. Mathis,
Susan Landau,
Nigel J. Cairns,
Erin Franklin,
Lisa TaylorReinwald,
Virginia Lee,
Magdalena Korecka,
Michal Figurski,
Karen Crawford,
Scott Neu,
Tatiana M. Foroud,
Steven G. Potkin,
Li Shen,
Kelley Faber,
Sungeun Kim,
Kwangsik Nho,
Lean Thal,
Neil Buckholtz,
Marilyn Albert,
Richard Frank,
John Hsiao
Publication year - 2021
Publication title -
jama neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.298
H-Index - 231
eISSN - 2168-6157
pISSN - 2168-6149
DOI - 10.1001/jamaneurol.2020.4986
Subject(s) - neurodegeneration , dementia , medicine , magnetic resonance imaging , cognitive decline , alzheimer's disease , pathology , oncology , psychology , disease , radiology
Key Points Question What is the potential of blood-based biomarkers for predicting and monitoring the progression of Alzheimer disease neurodegeneration? Findings In this cohort study that included 1113 participants from the multicentric Alzheimer’s Disease Neuroimaging Initiative study, baseline and longitudinal increases of tau phosphorylated at threonine 181 (p-tau181) in blood plasma were associated with progressive, longitudinal neurodegeneration in brain regions characteristic for Alzheimer disease, as well as with cognitive decline, only among participants with elevated brain amyloid-β. Neurofilament light chain in plasma, however, was associated with disease progression independent of amyloid-β and plasma p-tau181. Meaning These findings suggest that plasma p-tau181, alone or combined with plasma neurofilament light chain, can be used as an accessible, minimally invasive biomarker to track Alzheimer disease progression.
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