Association of Chronic Active Multiple Sclerosis Lesions With Disability In Vivo | Zendy

Martina Absinta | Zendy; Pascal Sati | Zendy; Federica Masuzzo | Zendy; Govind Nair | Zendy; Varun Sethi | Zendy; Hadar Kolb | Zendy; Joan Ohayon | Zendy; Tianxia Wu | Zendy; Irene Cortese | Zendy; Daniel S. Reich | Zendy

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Association of Chronic Active Multiple Sclerosis Lesions With Disability In Vivo

Author(s) -

Martina Absinta,

Pascal Sati,

Federica Masuzzo,

Govind Nair,

Varun Sethi,

Hadar Kolb,

Joan Ohayon,

Tianxia Wu,

Irene Cortese,

Daniel S. Reich

Publication year - 2019

Publication title -

jama neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.298

H-Index - 231

eISSN - 2168-6157

pISSN - 2168-6149

DOI - 10.1001/jamaneurol.2019.2399

Subject(s) - medicine , multiple sclerosis , magnetic resonance imaging , lesion , natural history study , pathological , radiology , pathology , disease , psychiatry

In multiple sclerosis (MS), chronic active lesions, which previously could only be detected at autopsy, can now be identified on susceptibility-based magnetic resonance imaging (MRI) in vivo as non-gadolinium-enhancing lesions with paramagnetic rims. Pathologically, they feature smoldering inflammatory demyelination at the edge, remyelination failure, and axonal degeneration. To our knowledge, the prospect of long-term in vivo monitoring makes it possible for the first time to determine their contribution to disability and value as a treatment target.

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