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Association of Sickle Cell Trait With Ischemic Stroke Among African Americans
Author(s) -
Hyacinth I. Hyacinth,
Cara L. Carty,
Samantha R. Seals,
Marguerite R. Irvin,
Rakhi P. Naik,
Gregory L. Burke,
Neil A. Zakai,
James G. Wilson,
Nora Franceschini,
Cheryl A. Winkler,
Victor A. David,
Jeffrey B. Kopp,
Suzanne E. Judd,
Robert J. Adams,
W.T. Longstreth,
Leonard E. Egede,
Daniel T. Lackland,
Herman A. Taylor,
JoAnn E. Manson,
Virginia J. Howard,
Matthew Allison,
Beatrice E. Gee,
Adolfo Correa,
Monika M. Safford,
Donna K. Arnett,
George Howard,
Alexander P. Reiner,
Mary Cushman
Publication year - 2018
Publication title -
jama neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.298
H-Index - 231
eISSN - 2168-6157
pISSN - 2168-6149
DOI - 10.1001/jamaneurol.2018.0571
Subject(s) - medicine , stroke (engine) , hazard ratio , sickle cell trait , prospective cohort study , population , proportional hazards model , demography , confidence interval , environmental health , disease , mechanical engineering , sociology , engineering
African Americans and individuals of African ancestry have a higher risk of stroke compared with non-Hispanic white individuals. Identifying the source of this disparity could provide an opportunity for clinical stroke risk stratification and more targeted therapy. Whether sickle cell trait (SCT) is an indicator of increased risk of ischemic stroke among African Americans is still unclear.

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