Efficacy of Oral Mixed Tocotrienols in Diabetic Peripheral Neuropathy
Author(s) -
Chee Peng Hor,
Wai-Yee Fung,
Hock Aun Ang,
Sheau Chin Lim,
Li Ying Kam,
S. Y. Sim,
Luen Hui Lim,
Wai Yee Choon,
Jia Woei Wong,
Alan Swee Hock Ch’ng,
Kelvin Khai Meng Beh,
Hong Chin Wee,
Loke Meng Ong,
Nurzalina Abdul Karim Khan,
Syed Azhar Syed Sulaiman,
Ibrahim Lutfi Shuaib,
Adlina Bakar,
Yusnita Yusof,
Y. Yusof,
Fatimah Abu Bakar,
Wei Shuong Tang,
Hoon Lang Teh,
Normala Abdul Wahid,
Suriani Saaidin,
Najihah Idris,
Chee Kin Yoon,
Hoon Ngoh Ong,
Jayasumithra T. Ganapathy,
Ching Ee Loo,
Michelle M. Samy,
Hadzlinda Zainal,
S. Dharan,
Bee Yen Ooi,
Pei Yeing Teoh,
Yi Loon Tye,
Chin Aun Yeoh,
Dy Win Low,
Irene Looi,
Kah Hay Yuen
Publication year - 2018
Publication title -
jama neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.298
H-Index - 231
eISSN - 2168-6157
pISSN - 2168-6149
DOI - 10.1001/jamaneurol.2017.4609
Subject(s) - medicine , peripheral neuropathy , diabetes mellitus , placebo , neuropathic pain , diabetic neuropathy , anesthesia , alternative medicine , pathology , endocrinology
Management of painful diabetic peripheral neuropathy remains challenging. Most therapies provide symptomatic relief with varying degrees of efficacy. Tocotrienols have modulatory effects on the neuropathy pathway and may reduce neuropathic symptoms with their antioxidative and anti-inflammatory activities.
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