Open AccessAssociations of the Top 20 Alzheimer Disease Risk Variants With Brain Amyloidosis
Author(s) -
Liana G. Apostolova,
Shan L. Risacher,
Tuğçe Duran,
Eddie Stage,
Naira Goukasian,
John D. West,
M. Triet,
Jonathan Grotts,
Holly Wilhalme,
Kwangsik Nho,
Meredith Phillips,
David Elashoff,
Andrew J. Saykin
Publication year - 2018
Publication title -
jama neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.298
H-Index - 231
eISSN - 2168-6157
pISSN - 2168-6149
DOI - 10.1001/jamaneurol.2017.4198
Subject(s) - genome wide association study , dementia , neuroimaging , psychology , medicine , oncology , alzheimer's disease , statistical parametric mapping , single nucleotide polymorphism , disease , genetics , biology , genotype , psychiatry , gene , magnetic resonance imaging , radiology
Late-onset Alzheimer disease (AD) is highly heritable. Genome-wide association studies have identified more than 20 AD risk genes. The precise mechanism through which many of these genes are associated with AD remains unknown.
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