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Seizures and Encephalitis in Myelin Oligodendrocyte Glycoprotein IgG Disease vs Aquaporin 4 IgG Disease
Author(s) -
Shahd Hamid,
Dan Whittam,
Mariyam Saviour,
Amal I. Alorainy,
Kerry Mutch,
Samantha Linaker,
Tom Solomon,
Maneesh Bhojak,
Mark Woodhall,
Patrick Waters,
Richard Appleton,
Martin Duddy,
Anu Jacob
Publication year - 2017
Publication title -
jama neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.298
H-Index - 231
eISSN - 2168-6157
pISSN - 2168-6149
DOI - 10.1001/jamaneurol.2017.3196
Subject(s) - neuromyelitis optica , medicine , myelin oligodendrocyte glycoprotein , interquartile range , multiple sclerosis , optic neuritis , immunology , autoimmune encephalitis , encephalitis , pediatrics , antibody , autoantibody , virus , experimental autoimmune encephalomyelitis
Antibodies to myelin oligodendrocyte glycoprotein IgG (MOG-IgG) are increasingly detected in patients with non-multiple sclerosis-related demyelination, some of whom manifest a neuromyelitis optica (NMO) phenotype. Cortical involvement, encephalopathy, and seizures are rare in aquaporin 4 antibody (AQP4-IgG)-related NMO in the white European population. However, the authors encountered several patients with seizures associated with MOG-IgG disease.

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