Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline | Zendy

Lei Yu | Zendy; Robert J. Dawe | Zendy; Patricia A. Boyle | Zendy; Chris Gaiteri | Zendy; Jingyun Yang | Zendy; Aron S. Buchman | Zendy; Julie A. Schneider | Zendy; Konstantinos Arfanakis | Zendy; Philip L. De Jager | Zendy; David A. Bennett | Zendy

Open Access

Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline

Author(s) -

Lei Yu,

Robert J. Dawe,

Patricia A. Boyle,

Chris Gaiteri,

Jingyun Yang,

Aron S. Buchman,

Julie A. Schneider,

Konstantinos Arfanakis,

Philip L. De Jager,

David A. Bennett

Publication year - 2017

Publication title -

jama neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.298

H-Index - 231

eISSN - 2168-6157

pISSN - 2168-6149

DOI - 10.1001/jamaneurol.2017.2807

Subject(s) - ex vivo , methylation , dna methylation , magnetic resonance imaging , functional magnetic resonance imaging , cognitive decline , dorsolateral prefrontal cortex , neuroimaging , prefrontal cortex , dementia , psychology , gene expression , neuroscience , biology , in vivo , medicine , pathology , cognition , genetics , gene , disease , radiology

Alteration of ex vivo magnetic resonance imaging transverse relaxation is associated with late-life cognitive decline even after controlling for common neuropathologic conditions. However, the underlying neurobiology of this association is unknown.

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