Low-Dose vs Standard-Dose Alteplase for Patients With Acute Ischemic Stroke | Zendy

Xia Wang | Zendy; Thompson Robinson | Zendy; TsongHai Lee | Zendy; Qiang Li | Zendy; Hisatomi Arima | Zendy; Philip M. Bath | Zendy; Laurent Billot | Zendy; Joseph P. Broderick | Zendy; Andrew M. Demchuk | Zendy; Geoffrey A. Donnan | Zendy; Jong S. Kim | Zendy; Pablo M. Lavados | Zendy; Richard I. Lindley | Zendy; Sheila Cristina Ouriques Martins | Zendy; Verónica V. Olavarría | Zendy; Jeyaraj Pandian | Zendy; Mark Parsons | Zendy; Octávio Marques PontesNeto | Zendy; Stefano Ricci | Zendy; Vijay K. Sharma | Zendy; Trung Quoc Nguyen | Zendy; JiGuang Wang | Zendy; Mark Woodward | Zendy; Craig S. Anderson | Zendy; John Chalmers | Zendy

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Low-Dose vs Standard-Dose Alteplase for Patients With Acute Ischemic Stroke

Author(s) -

Xia Wang,

Thompson Robinson,

TsongHai Lee,

Qiang Li,

Hisatomi Arima,

Philip M. Bath,

Laurent Billot,

Joseph P. Broderick,

Andrew M. Demchuk,

Geoffrey A. Donnan,

Jong S. Kim,

Pablo M. Lavados,

Richard I. Lindley,

Sheila Cristina Ouriques Martins,

Verónica V. Olavarría,

Jeyaraj Pandian,

Mark Parsons,

Octávio Marques PontesNeto,

Stefano Ricci,

Vijay K. Sharma,

Trung Quoc Nguyen,

JiGuang Wang,

Mark Woodward,

Craig S. Anderson,

John Chalmers

Publication year - 2017

Publication title -

jama neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.298

H-Index - 231

eISSN - 2168-6157

pISSN - 2168-6149

DOI - 10.1001/jamaneurol.2017.2286

Subject(s) - medicine , thrombolysis , randomization , randomized controlled trial , intracerebral hemorrhage , stroke (engine) , clinical trial , clinical endpoint , bolus (digestion) , anesthesia , surgery , myocardial infarction , glasgow coma scale , mechanical engineering , engineering

A lower dose of intravenous alteplase appears to be a safer treatment option than the standard dose, reducing the risk of symptomatic intracerebral hemorrhage. There is uncertainty, however, over how this effect translates into an overall clinical benefit for patients with acute ischemic stroke (AIS).

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