Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau–Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers | Zendy

Richard Rubenstein | Zendy; Binggong Chang | Zendy; John K. Yue | Zendy; Allen W. Chiu | Zendy; Ethan A. Winkler | Zendy; Ava M. Puccio | Zendy; Ramon DiazArrastia | Zendy; Esther L. Yuh | Zendy; Pratik Mukherjee | Zendy; Alex B. Valadka | Zendy; Wayne A. Gordon | Zendy; David O. Okonkwo | Zendy; Peter Davies | Zendy; Sanjeev Agarwal | Zendy; Fan Lin | Zendy; George Anis Sarkis | Zendy; Hamad Yadikar | Zendy; Zhihui Yang | Zendy; Geoffrey T. Manley | Zendy; Kevin Wang | Zendy; Shelly R. Cooper | Zendy; Kristen Dams-O’Connor | Zendy; Allison J. Borrasso | Zendy; Tomoo Inoue | Zendy; Andrew I.R. Maas | Zendy; David Me | Zendy; David M. Schnyer | Zendy; Mary J. Vassar | Zendy

Open Access

Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau–Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers

Author(s) -

Richard Rubenstein,

Binggong Chang,

John K. Yue,

Allen W. Chiu,

Ethan A. Winkler,

Ava M. Puccio,

Ramon DiazArrastia,

Esther L. Yuh,

Pratik Mukherjee,

Alex B. Valadka,

Wayne A. Gordon,

David O. Okonkwo,

Peter Davies,

Sanjeev Agarwal,

Fan Lin,

George Anis Sarkis,

Hamad Yadikar,

Zhihui Yang,

Geoffrey T. Manley,

Kevin Wang,

Shelly R. Cooper,

Kristen Dams-O’Connor,

Allison J. Borrasso,

Tomoo Inoue,

Andrew I.R. Maas,

David Me,

David M. Schnyer,

Mary J. Vassar

Publication year - 2017

Publication title -

jama neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.298

H-Index - 231

eISSN - 2168-6157

pISSN - 2168-6149

DOI - 10.1001/jamaneurol.2017.0655

Subject(s) - traumatic brain injury , medicine , oncology , psychiatry

Annually in the United States, at least 3.5 million people seek medical attention for traumatic brain injury (TBI). The development of therapies for TBI is limited by the absence of diagnostic and prognostic biomarkers. Microtubule-associated protein tau is an axonal phosphoprotein. To date, the presence of the hypophosphorylated tau protein (P-tau) in plasma from patients with acute TBI and chronic TBI has not been investigated.

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