Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex | Zendy

Jorge Sepulcre | Zendy; Michel J. Grothe | Zendy; Mert R. Sabuncu | Zendy; Jasmeer P. Chhatwal | Zendy; Aaron P. Schultz | Zendy; Bernard Hanseeuw | Zendy; Georges El Fakhri | Zendy; Reisa A. Sperling | Zendy; Keith A. Johnson | Zendy

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Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex

Author(s) -

Jorge Sepulcre,

Michel J. Grothe,

Mert R. Sabuncu,

Jasmeer P. Chhatwal,

Aaron P. Schultz,

Bernard Hanseeuw,

Georges El Fakhri,

Reisa A. Sperling,

Keith A. Johnson

Publication year - 2017

Publication title -

jama neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.298

H-Index - 231

eISSN - 2168-6157

pISSN - 2168-6149

DOI - 10.1001/jamaneurol.2017.0263

Subject(s) - temporal lobe , pathology , pittsburgh compound b , temporal cortex , alzheimer's disease , cerebral cortex , neuroscience , voxel , human brain , cortex (anatomy) , positron emission tomography , amyloid (mycology) , psychology , medicine , disease , radiology , epilepsy

Abnormal accumulation of tau and amyloid-β (Aβ) proteins in the human brain are 2 pathologic hallmarks of Alzheimer disease (AD). Because pathologic processes begin decades before the onset of the clinical manifestations, the study of the cortical distribution of early-stage pathologic alterations is critical in understanding the underpinnings of the disease.

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