Imaging of Glial Cell Activation and White Matter Integrity in Brains of Active and Recently Retired National Football League Players | Zendy

Jennifer M. Coughlin | Zendy; Yuchuan Wang | Zendy; Il Minn | Zendy; Nicholas Bienko | Zendy; Emily B. Ambinder | Zendy; Xin Xu | Zendy; Matthew E. Peters | Zendy; John W. Dougherty | Zendy; Melin Vranešić | Zendy; Soo Min Koo | Zendy; Hye-Hyun Ahn | Zendy; Merton Lee | Zendy; C.A. Cottrell | Zendy; Haris I. Sair | Zendy; Akira Sawa | Zendy; Cynthia A. Munro | Zendy; Christopher J. Nowinski | Zendy; Robert F. Dannals | Zendy; Constantine G. Lyketsos | Zendy; Michael Kassiou | Zendy; Gwenn S. Smith | Zendy; Brian Caffo | Zendy; Susumu Mori | Zendy; Tomás R. Guilarte | Zendy; Martin G. Pomper | Zendy

Open Access

Imaging of Glial Cell Activation and White Matter Integrity in Brains of Active and Recently Retired National Football League Players

Author(s) -

Jennifer M. Coughlin,

Yuchuan Wang,

Il Minn,

Nicholas Bienko,

Emily B. Ambinder,

Xin Xu,

Matthew E. Peters,

John W. Dougherty,

Melin Vranešić,

Soo Min Koo,

Hye-Hyun Ahn,

Merton Lee,

C.A. Cottrell,

Haris I. Sair,

Akira Sawa,

Cynthia A. Munro,

Christopher J. Nowinski,

Robert F. Dannals,

Constantine G. Lyketsos,

Michael Kassiou,

Gwenn S. Smith,

Brian Caffo,

Susumu Mori,

Tomás R. Guilarte,

Martin G. Pomper

Publication year - 2016

Publication title -

jama neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.298

H-Index - 231

eISSN - 2168-6157

pISSN - 2168-6149

DOI - 10.1001/jamaneurol.2016.3764

Subject(s) - concussion , traumatic brain injury , chronic traumatic encephalopathy , translocator protein , white matter , diffusion mri , medicine , psychology , magnetic resonance imaging , neuroscience , poison control , microglia , physical medicine and rehabilitation , injury prevention , psychiatry , radiology , inflammation , environmental health

Microglia, the resident immune cells of the central nervous system, play an important role in the brain's response to injury and neurodegenerative processes. It has been proposed that prolonged microglial activation occurs after single and repeated traumatic brain injury, possibly through sports-related concussive and subconcussive injuries. Limited in vivo brain imaging studies months to years after individuals experience a single moderate to severe traumatic brain injury suggest widespread persistent microglial activation, but there has been little study of persistent glial cell activity in brains of athletes with sports-related traumatic brain injury.

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