Open AccessLongitudinal β-Amyloid Deposition and Hippocampal Volume in Preclinical Alzheimer Disease and Suspected Non–Alzheimer Disease Pathophysiology
Author(s) -
Brian A. Gordon,
Tyler Blazey,
Yi Su,
Anne M. Fagan,
David M. Holtzman,
John C. Morris,
Tammie L.S. Benzinger
Publication year - 2016
Publication title -
jama neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.298
H-Index - 231
eISSN - 2168-6157
pISSN - 2168-6149
DOI - 10.1001/jamaneurol.2016.2642
Subject(s) - pathophysiology , alzheimer's disease , disease , neuroscience , medicine , amyloid (mycology) , hippocampal formation , hippocampus , pathology , psychology
Preclinical Alzheimer disease (AD) can be staged using a 2-factor model denoting the presence or absence of β-amyloid (Aβ+/-) and neurodegeneration (ND+/-). The association of these stages with longitudinal biomarker outcomes is unknown.
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