Plasma Coenzyme Q10 Levels in Patients With Multiple System Atrophy
Author(s) -
Jun Mitsui,
Takashi Matsukawa,
Tsutomu Yasuda,
Hiroyuki Ishiura,
Shoji Tsuji
Publication year - 2016
Publication title -
jama neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.298
H-Index - 231
eISSN - 2168-6157
pISSN - 2168-6149
DOI - 10.1001/jamaneurol.2016.1325
Subject(s) - medicine , coenzyme q10 , parkinsonism , gastroenterology , atrophy , pathogenesis , parkinson's disease , disease
Multiple system atrophy (MSA) is an intractable neurodegenerative disease characterized by autonomic failure in addition to various combinations of parkinsonism, cerebellar ataxia, and pyramidal dysfunction. It has recently been reported that functionally impaired variants of COQ2, which encodes an essential enzyme in the biosynthetic pathway of coenzyme Q10 (CoQ10), are associated with MSA. However, little is known about the role of CoQ10 in the pathogenesis of MSA.
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