Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults | Zendy

Shan L. Risacher | Zendy; Brenna C. McDonald | Zendy; Eileen F. Tallman | Zendy; John D. West | Zendy; Martin R. Farlow | Zendy; Fredrick Unverzagt | Zendy; Sujuan Gao | Zendy; Malaz Boustani | Zendy; Paul K. Crane | Zendy; Ronald Petersen | Zendy; Clifford R. Jack | Zendy; William J. Jagust | Zendy; Paul Aisen | Zendy; Michael W. Weiner | Zendy; Andrew J. Saykin | Zendy

Open Access

Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults

Author(s) -

Shan L. Risacher,

Brenna C. McDonald,

Eileen F. Tallman,

John D. West,

Martin R. Farlow,

Fredrick Unverzagt,

Sujuan Gao,

Malaz Boustani,

Paul K. Crane,

Ronald Petersen,

Clifford R. Jack,

William J. Jagust,

Paul Aisen,

Michael W. Weiner,

Andrew J. Saykin

Publication year - 2016

Publication title -

jama neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.298

H-Index - 231

eISSN - 2168-6157

pISSN - 2168-6149

DOI - 10.1001/jamaneurol.2016.0580

Subject(s) - alzheimer's disease neuroimaging initiative , neuroimaging , dementia , psychology , cognition , atrophy , anticholinergic , cognitive decline , medicine , psychiatry , disease

The use of anticholinergic (AC) medication is linked to cognitive impairment and an increased risk of dementia. To our knowledge, this is the first study to investigate the association between AC medication use and neuroimaging biomarkers of brain metabolism and atrophy as a proxy for understanding the underlying biology of the clinical effects of AC medications.

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