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Hypothetical Preclinical Alzheimer Disease Groups and Longitudinal Cognitive Change
Author(s) -
Anja Soldan,
Corinne Pettigrew,
Qing Cai,
MeiCheng Wang,
Abhay Moghekar,
Richard O’Brien,
Ola A. Selnes,
Marilyn Albert
Publication year - 2016
Publication title -
jama neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.298
H-Index - 231
eISSN - 2168-6157
pISSN - 2168-6149
DOI - 10.1001/jamaneurol.2016.0194
Subject(s) - cognition , dementia , psychology , recall , alzheimer's disease , cognitive decline , audiology , effects of sleep deprivation on cognitive performance , disease , medicine , biomarker , oncology , psychiatry , cognitive psychology , biochemistry , chemistry
Clinical trials testing treatments for Alzheimer disease (AD) are increasingly focused on cognitively normal individuals in the preclinical phase of the disease. To optimize observing a treatment effect, such trials need to enroll cognitively normal individuals likely to show cognitive decline over the duration of the trial.

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