Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease
Author(s) -
Jennifer S. Yokoyama,
Yunpeng Wang,
Andrew J. Schork,
Wesley K. Thompson,
Celeste M. Karch,
Carlos Cruchaga,
Linda K. McEvoy,
Aree Witoelar,
ChiHua Chen,
Dominic Holland,
James B. Brewer,
André Franke,
William P. Dillon,
David M. Wilson,
Pratik Mukherjee,
Christopher P. Hess,
Zachary Miller,
Luke W. Bonham,
Jeffrey Shen,
Gil D. Rabinovici,
Howard J. Rosen,
Bruce L. Miller,
Bradley T. Hyman,
Gerard D. Schellenberg,
Tom H. Karlsen,
Ole A. Andreassen,
Anders M. Dale,
Rahul S. Desikan
Publication year - 2016
Publication title -
jama neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.298
H-Index - 231
eISSN - 2168-6157
pISSN - 2168-6149
DOI - 10.1001/jamaneurol.2016.0150
Subject(s) - disease , genome wide association study , dementia , alzheimer's disease , odds ratio , medicine , bioinformatics , single nucleotide polymorphism , genetics , biology , genotype , gene
Late-onset Alzheimer disease (AD), the most common form of dementia, places a large burden on families and society. Although epidemiological and clinical evidence suggests a relationship between inflammation and AD, their relationship is not well understood and could have implications for treatment and prevention strategies.
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