Pathophysiologic Mechanisms of Cerebral Ischemia and Diffusion Hypoxia in Traumatic Brain Injury | Zendy

Tonny Veenith | Zendy; Eleanor L. Carter | Zendy; Thomas Geeraerts | Zendy; Julia Grossac | Zendy; Virginia Newcombe | Zendy; Joanne Outtrim | Zendy; Gloria S. Gee | Zendy; Victoria Lupson | Zendy; Rob Smith | Zendy; Franklin I. Aigbirhio | Zendy; Tim D. Fryer | Zendy; Young T. Hong | Zendy; David Me | Zendy; Jonathan Coles | Zendy

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Pathophysiologic Mechanisms of Cerebral Ischemia and Diffusion Hypoxia in Traumatic Brain Injury

Author(s) -

Tonny Veenith,

Eleanor L. Carter,

Thomas Geeraerts,

Julia Grossac,

Virginia Newcombe,

Joanne Outtrim,

Gloria S. Gee,

Victoria Lupson,

Rob Smith,

Franklin I. Aigbirhio,

Tim D. Fryer,

Young T. Hong,

David Me,

Jonathan Coles

Publication year - 2016

Publication title -

jama neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.298

H-Index - 231

eISSN - 2168-6157

pISSN - 2168-6149

DOI - 10.1001/jamaneurol.2016.0091

Subject(s) - hypoxia (environmental) , pathophysiology , ischemia , medicine , traumatic brain injury , cerebral hypoxia , cerebral ischaemia , neuroscience , cardiology , psychology , psychiatry , oxygen , chemistry , organic chemistry

Combined oxygen 15-labeled positron emission tomography (15O PET) and brain tissue oximetry have demonstrated increased oxygen diffusion gradients in hypoxic regions after traumatic brain injury (TBI). These data are consistent with microvascular ischemia and are supported by pathologic studies showing widespread microvascular collapse, perivascular edema, and microthrombosis associated with selective neuronal loss. Fluorine 18-labeled fluoromisonidazole ([18F]FMISO), a PET tracer that undergoes irreversible selective bioreduction within hypoxic cells, could confirm these findings.

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