Open AccessImpaired Cerebrovascular Reactivity in Multiple Sclerosis
Author(s) -
Olga Marshall,
Hanzhang Lu,
JeanChristophe Brisset,
Feng Xu,
Peiying Liu,
Joseph Herbert,
Robert I. Grossman,
Yulin Ge
Publication year - 2014
Publication title -
jama neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.298
H-Index - 231
eISSN - 2168-6157
pISSN - 2168-6149
DOI - 10.1001/jamaneurol.2014.1668
Subject(s) - hypercapnia , cerebral blood flow , medicine , magnetic resonance imaging , normocapnia , cardiology , cerebral perfusion pressure , perfusion , multiple sclerosis , anesthesia , atrophy , white matter , radiology , respiratory system , psychiatry
Cerebrovascular reactivity (CVR) is an inherent indicator of the dilatory capacity of cerebral arterioles for a vasomotor stimulus for maintaining a spontaneous and instant increase of cerebral blood flow (CBF) in response to neural activation. The integrity of this mechanism is essential to preserving healthy neurovascular coupling; however, to our knowledge, no studies have investigated whether there are CVR abnormalities in multiple sclerosis (MS).
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