Open AccessEffects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease
Author(s) -
Adam C. Naj,
Gyungah Jun,
Christiane Reitz,
Brian W. Kunkle,
William Perry,
Yo Son Park,
Gary W. Beecham,
Ruchita Rajbhandary,
Kara L. HamiltonNelson,
Li-San Wang,
John Kauwe,
Matthew J. Huentelman,
Amanda Myers,
Thomas D. Bird,
Bradley F. Boeve,
Clinton T. Baldwin,
Gail P. Jarvik,
Paul K. Crane,
Ekaterina Rogaeva,
M. Michael Barmada,
F. Yesim Demirci,
Carlos Cruchaga,
Patricia L. Kramer,
Nilüfer ErtekinTaner,
John Hardy,
Neill R. GraffRadford,
Robert C. Green,
Eric B. Larson,
Peter St GeorgeHyslop,
Joseph D. Buxbaum,
Denis A. Evans,
Julie A. Schneider,
Kathryn L. Lunetta,
M. Ilyas Kamboh,
Andrew J. Saykin,
Eric M. Reiman,
Philip L. De Jager,
David Bennett,
John C. Morris,
Thomas J. Montine,
Alison Goate,
Deborah Blacker,
Debby W. Tsuang,
Hákon Hákonarson,
Walter A. Kukull,
Tatiana Foroud,
Eden R. Martin,
Jonathan L. Haines,
Richard Mayeux,
Lindsay A. Farrer,
Gerard D. Schellenberg,
Margaret A. PericakVance,
Marilyn S. Albert,
Roger L. Albin,
Liana G. Apostolova,
Steven E. Arnold,
Robert W. Barber,
Lisa L. Barnes,
Thomas G. Beach,
James T. Becker,
Duane Beekly,
Eileen H. Bigio,
James D. Bowen,
Adam Boxer,
James R. Burke,
Nigel J. Cairns,
Laura B. Cantwell,
Chuanhai Cao,
Chris Carlson,
Regina M. Carney,
Minerva M. Carrasquillo,
Steven L. Carroll,
Helena C. Chui,
David G. Clark,
Jason J. Corneveaux,
David H. Cribbs,
Elizabeth Crocco,
Charles DeCarli,
Steven T. DeKosky,
Malcolm Dick,
Dennis W. Dickson,
Ranjan Duara,
Kelley M. Faber,
Kenneth B. Fallon,
Martin R. Farlow,
Steven H. Ferris,
Matthew P. Frosch,
Douglas Galasko,
Mary Ganguli,
Marla Gearing,
Daniel H. Geschwind,
Bernardino Ghetti,
John R. Gilbert,
Jonathan D. Glass,
John H. Growdon,
Ronald L. Hamilton,
Lindy E. Harrell,
Elizabeth Head,
Lawrence S. Honig,
Christine M. Hulette,
Bradley T. Hyman,
Gregory A. Jicha,
LeeWay Jin,
Anna Karydas,
Jeffrey Kaye,
Ronald Kim,
Edward H. Koo,
Neil W. Kowall,
Joel H. Kramer,
Frank M. LaFerla,
James J. Lah,
James B. Leverenz,
Allan I. Levey,
Ge Li,
Andrew P. Lieberman,
ChiaoFeng Lin,
Oscar L. López,
Constantine G. Lyketsos,
Wendy J. Mack,
Frank Martiniuk,
Deborah C. Mash,
Eliezer Masliah,
Wayne C. McCormick,
Susan M. McCurry,
Andrew McDavid,
Ann C. McKee,
Marsel Mesulam,
Bruce L. Miller,
Carol A. Miller,
Joshua W. Miller,
Jill R. Murrell,
John Olichney,
V. Shane Pankratz,
Joseph E. Parisi,
Henry L. Paulson,
Elaine R. Peskind,
Ronald Petersen,
Aimee Pierce,
Wayne W. Poon,
Huntington Potter,
Joseph F. Quinn,
Ashok Raj,
Murray A. Raskind,
Barry Reisberg,
John M. Ringman,
Erik D. Roberson,
Howard J. Rosen,
Roger N. Rosenberg,
Mary Sano,
Lon S. Schneider,
William W. Seeley,
Amanda Smith,
Joshua A. Sonnen,
Salvatore Spina,
Robert A. Stern,
Rudolph E. Tanzi,
Tricia A. ThorntonWells,
John Q. Trojanowski,
Juan C. Troncoso,
Otto Valladares,
Vivianna M. Van Deerlin,
Linda J. Van Eldik,
Badri N. Vardarajan,
Harry V. Vinters,
Jean Paul Vonsattel,
Sandra Weıntraub,
Kathleen A. WelshBohmer,
Jennifer Williamson,
Sarah Wishnek,
Randall L. Woltjer,
Clinton B. Wright,
Steven G. Younkin,
ChangEn Yu,
Lei Yu
Publication year - 2014
Publication title -
jama neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.298
H-Index - 231
eISSN - 2168-6157
pISSN - 2168-6149
DOI - 10.1001/jamaneurol.2014.1491
Subject(s) - apolipoprotein e , disease , alzheimer's disease , age of onset , single nucleotide polymorphism , genotype , genome wide association study , medicine , genetics , biology , oncology , gene
Because APOE locus variants contribute to risk of late-onset Alzheimer disease (LOAD) and to differences in age at onset (AAO), it is important to know whether other established LOAD risk loci also affect AAO in affected participants.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom