Open AccessEpisodic Bradycardia as Neurocardiac Prodrome to Voltage-Gated Potassium Channel Complex/Leucine-Rich, Glioma Inactivated 1 Antibody Encephalitis
Author(s) -
Georges Naasan,
Sarosh R. Irani,
Brianne M. Bettcher,
Michael D. Geschwind,
Jeffrey M. Gelfand
Publication year - 2014
Publication title -
jama neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.298
H-Index - 231
eISSN - 2168-6157
pISSN - 2168-6149
DOI - 10.1001/jamaneurol.2014.1234
Subject(s) - prodrome , encephalitis , autoimmune encephalitis , medicine , bradycardia , encephalopathy , limbic encephalitis , hyponatremia , pathology , immunology , psychiatry , heart rate , virus , psychosis , blood pressure
Voltage-gated potassium channel complex antibody (VGKCc-Ab) encephalitis is an immunotherapy-responsive syndrome usually associated with causative antibodies that target the leucine-rich, glioma inactivated 1 (LGI1) protein. Although it is expressed throughout the brain, LGI1 is not known to be expressed in cardiac tissue. We describe a novel neurocardiac prodrome of VGKCc-Ab/LGI1-encephalitis.
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