Effect of Apolipoprotein E Genotype and Diet on Apolipoprotein E Lipidation and Amyloid Peptides | Zendy

Angela J. Hanson | Zendy; Jennifer L. Bayer-Carter | Zendy; Pattie S. Green | Zendy; Thomas J. Montine | Zendy; Charles W. Wilkinson | Zendy; Laura D. Baker | Zendy; G. Stennis Watson | Zendy; Laura M. Bonner | Zendy; Maureen Callaghan | Zendy; James B. Leverenz | Zendy; Elaine C. Tsai | Zendy; Nadia Postupna | Zendy; Jing Zhang | Zendy; Johanna W. Lampe | Zendy; Suzanne Craft | Zendy

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Effect of Apolipoprotein E Genotype and Diet on Apolipoprotein E Lipidation and Amyloid Peptides

Author(s) -

Angela J. Hanson,

Jennifer L. Bayer-Carter,

Pattie S. Green,

Thomas J. Montine,

Charles W. Wilkinson,

Laura D. Baker,

G. Stennis Watson,

Laura M. Bonner,

Maureen Callaghan,

James B. Leverenz,

Elaine C. Tsai,

Nadia Postupna,

Jing Zhang,

Johanna W. Lampe,

Suzanne Craft

Publication year - 2013

Publication title -

jama neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.298

H-Index - 231

eISSN - 2168-6157

pISSN - 2168-6149

DOI - 10.1001/jamaneurol.2013.396

Subject(s) - apolipoprotein e , medicine , endocrinology , glycemic index , cognitive decline , cerebrospinal fluid , apolipoprotein b , glycemic , dementia , disease , cholesterol , insulin

Sporadic Alzheimer disease (AD) is caused in part by decreased clearance of the β-amyloid (Aβ) peptide breakdown products. Lipid-depleted (LD) apolipoproteins are less effective at binding and clearing Aβ, and LD Aβ peptides are more toxic to neurons. However, not much is known about the lipid states of these proteins in human cerebrospinal fluid.

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