Open AccessEvaluation of Potential Infectivity of Alzheimer and Parkinson Disease Proteins in Recipients of Cadaver-Derived Human Growth Hormone
Author(s) -
David J. Irwin,
Joseph Y. Abrams,
Lawrence B. Schonberger,
Ellen W. Leschek,
James L. Mills,
Virginia M.Y. Lee,
John Q. Trojanowski
Publication year - 2013
Publication title -
jama neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.298
H-Index - 231
eISSN - 2168-6157
pISSN - 2168-6149
DOI - 10.1001/jamaneurol.2013.1933
Subject(s) - cohort , medicine , autopsy , disease , creutzfeldt jakob syndrome , human brain , pathology , prion protein , psychiatry
Growing evidence of cell-to-cell transmission of neurodegenerative disease (ND)-associated proteins (NDAPs) (ie, tau, Aβ, and α-synuclein) suggests possible similarities to the infectious prion protein (PrPsc) in spongiform encephalopathies. There are limited data on the potential human-to-human transmission of NDAPs associated with Alzheimer disease (AD) and other non-PrPsc ND.
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