Genomic Epidemiology of SARS-CoV-2 Infection During the Initial Pandemic Wave and Association With Disease Severity | Zendy

Frank Esper | Zendy; YuWei Cheng | Zendy; Thamali M. Adhikari | Zendy; Zheng Jin Tu | Zendy; Derek Li | Zendy; Erik A. Li | Zendy; Daniel H. Farkas | Zendy; Gary W. Procop | Zendy; Jennifer S. Ko | Zendy; Timothy A. Chan | Zendy; Lara Jehi | Zendy; Brian P. Rubin | Zendy; Jing Li | Zendy

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Genomic Epidemiology of SARS-CoV-2 Infection During the Initial Pandemic Wave and Association With Disease Severity

Author(s) -

Frank Esper,

YuWei Cheng,

Thamali M. Adhikari,

Zheng Jin Tu,

Derek Li,

Erik A. Li,

Daniel H. Farkas,

Gary W. Procop,

Jennifer S. Ko,

Timothy A. Chan,

Lara Jehi,

Brian P. Rubin,

Jing Li

Publication year - 2021

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2021.7746

Subject(s) - pandemic , epidemiology , covid-19 , disease , virology , medicine , genome wide association study , biology , infectious disease (medical specialty) , genotype , outbreak , genetics , single nucleotide polymorphism , gene

Key Points Question Are SARS-CoV-2 variants, virus clades, or clade groups associated with disease severity and patient outcomes? Findings In this cross-sectional study of 302 SARS-CoV-2 isolates, 6 different Global Initiative on Sharing All Influenza Data clades circulated in the community followed by a rapid reduction in clade diversity. Several variants, including 23403A>G (D614G), were significantly associated with lower hospitalization rates and increased patient survival. Meaning These findings suggest that SARS-CoV-2 clade assignment is an important factor that may aid in estimating patient outcomes.

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