Association of Adherence to Surfactant Best Practice Uses With Clinical Outcomes Among Neonates in Sweden | Zendy

Pontus Challis | Zendy; Per Nydert | Zendy; Stellan Håkansson | Zendy; Mikael Norman | Zendy

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Association of Adherence to Surfactant Best Practice Uses With Clinical Outcomes Among Neonates in Sweden

Author(s) -

Pontus Challis,

Per Nydert,

Stellan Håkansson,

Mikael Norman

Publication year - 2021

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2021.7269

Subject(s) - medicine , gestational age , respiratory distress , surfactant therapy , pediatrics , retinopathy of prematurity , mechanical ventilation , population , apgar score , bronchopulmonary dysplasia , cohort , birth weight , pregnancy , anesthesia , genetics , environmental health , biology

Key Points Question What strategies for surfactant treatment of newborn infants are used, and how are these strategies associated with outcomes? Findings In this cohort study of 5209 infants who received 7980 surfactant administrations, late surfactant treatment (>2 hours after birth) was provided for 39% of very preterm infants and associated with higher neonatal morbidity. Off-label use occurred in 19% of infants without any association to outcome, and treatment omissions were associated with lower survival. Meaning In this study, adherence to best practices for surfactant use in newborn infants varied, with important clinical implications for neonatal outcomes.

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