Open AccessRisk of Infection Associated With Administration of Intravenous Iron
Author(s) -
Akshay Shah,
Killian Donovan,
Claire Seeley,
Edward Dickson,
Antony Palmer,
Carolyn Dorée,
Susan J Brunskill,
Jack Reid,
Austin G. Acheson,
Anita Sugavanam,
Edward Litton,
Simon Stanworth
Publication year - 2021
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2021.33935
Subject(s) - medicine , randomized controlled trial , data extraction , medline , clinical trial , meta analysis , intravenous iron , relative risk , anemia , blood transfusion , pediatrics , intensive care medicine , emergency medicine , confidence interval , iron deficiency , political science , law
Key Points Question In patients who require treatment with intravenous iron, what is the evidence that this intervention increases the risk of developing a new infection? Findings In this systematic review and meta-analysis of 154 randomized clinical trials that included 32 920 participants, intravenous iron was associated with an increased risk of infection. Meaning The results of this study suggest that, despite broad advocacy in clinical guidelines, intravenous iron may increase the risk of infection, which must be balanced with the potential benefits of treating anemia and reducing blood transfusion requirements.
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