Open AccessAssociations of Serum Uric Acid Levels With Macrovascular and Renal Microvascular Dysfunction Among Individuals From Sub-Saharan Africa
Author(s) -
Charles HayfronBenjamin,
BertJan H. van den Born,
Albert Amoah,
Anke H. Maitlandvan der Zee,
Karlijn Meeks,
Erik Beune,
Kerstin KlipsteinGrobusch,
Charles Agyemang
Publication year - 2021
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2021.28985
Subject(s) - medicine , albuminuria , macrovascular disease , diabetes mellitus , population , quartile , cross sectional study , uric acid , endothelial dysfunction , renal function , blood pressure , type 2 diabetes , demography , endocrinology , confidence interval , environmental health , pathology , sociology
Key Points Question Are high or low serum uric acid levels associated with vascular dysfunction in individuals with sub-Saharan African ancestry? Findings In this cross-sectional analysis that included 4919 people from Ghana, elevated serum uric acid level was significantly associated with higher odds of kidney microvascular dysfunction, but not coronary artery disease or peripheral artery disease, after adjusting for a wide range of cardiometabolic risk factors. Elevated blood pressure significantly mediated the association between high serum uric acid level and kidney microvascular dysfunction; poor glycemic control, obesity, and inflammation did not significantly mediate the association. Meaning The findings of this study suggest that individuals from sub-Saharan Africa with elevated serum uric acid levels may benefit from periodic screening for kidney microvascular dysfunction to aid early detection or treatment.
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