Open AccessAssessment of Breathomics Testing Using High-Pressure Photon Ionization Time-of-Flight Mass Spectrometry to Detect Esophageal Cancer
Author(s) -
Qi Huang,
Shaodong Wang,
Qingyun Li,
Peiyu Wang,
JianFeng Li,
Shushi Meng,
Hang Li,
Hao Wu,
Yu Qi,
Xiangnan Li,
Yang Yang,
Song Zhao,
Mantang Qiu
Publication year - 2021
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2021.27042
Subject(s) - receiver operating characteristic , medicine , esophageal cancer , cancer
Key Points Question Could esophageal cancer be detected by testing breathomics using high-pressure photon ionization time-of-flight mass spectrometry (HPPI-TOFMS)? Findings In this diagnostic study of 675 patients with and without cancer, esophageal cancer was accurately detected by testing breathomics with a sensitivity of 97.83% and specificity of 83.72% in the validation data set. Meaning These findings suggest that testing breathomics could help to improve the diagnosis of esophageal cancer.
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