The Triglyceride-Glucose Index and Obesity-Related Risk of End-Stage Kidney Disease in Austrian Adults | Zendy

Josef Fritz | Zendy; Wolfgang Brozek | Zendy; Hans Concin | Zendy; Gabriele Nagel | Zendy; Julia Kerschbaum | Zendy; Karl Lhotta | Zendy; Hanno Ulmer | Zendy; Emanuel Zitt | Zendy

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The Triglyceride-Glucose Index and Obesity-Related Risk of End-Stage Kidney Disease in Austrian Adults

Author(s) -

Josef Fritz,

Wolfgang Brozek,

Hans Concin,

Gabriele Nagel,

Julia Kerschbaum,

Karl Lhotta,

Hanno Ulmer,

Emanuel Zitt

Publication year - 2021

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2021.2612

Subject(s) - medicine , body mass index , population , kidney disease , overweight , obesity , dialysis , kidney transplantation , transplantation , environmental health

Key Points Question To what extent does the triglyceride-glucose index, a novel measure of insulin resistance, explain the association between body mass index and end-stage kidney disease risk? Findings In this population-based cohort study of 176 420 Austrian participants, the triglyceride-glucose index was significantly associated with incident end-stage kidney disease risk. Approximately 40% of the association between body mass index and end-stage kidney disease was mediated through the triglyceride-glucose index. Meaning The findings of this study appear to support the hypothesis of insulin resistance being an important intermediate in the association between obesity and end-stage kidney disease.

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