Open AccessAssociation of Timing and Duration of Prenatal Analgesic Opioid Exposure With Attention-Deficit/Hyperactivity Disorder in Children
Author(s) -
Johanne Naper Trønnes,
Angela Lupattelli,
Marte Handal,
Svetlana Skurtveit,
Eivind Ystrøm,
Hedvig Nordeng
Publication year - 2021
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2021.24324
Subject(s) - medicine , attention deficit hyperactivity disorder , pregnancy , cohort , hazard ratio , analgesic , confounding , pediatrics , cohort study , opioid use disorder , opioid , psychiatry , confidence interval , genetics , biology , receptor
Key Points Question Is prenatal analgesic opioid exposure associated with attention-deficit/hyperactivity disorder (ADHD) in children? Findings In this cohort study of 73 480 children, with a mean follow-up of 11 years, no association between timing of analgesic opioid exposure during pregnancy and ADHD was found. The risk of ADHD diagnosis was elevated after exposure to opioids for 5 or more weeks compared with exposure for 4 weeks or less. Meaning The increased risk of ADHD observed in this study may be driven by longer duration of exposure; however, the role of residual or unmeasured confounding cannot be excluded, and this finding requires further study.
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