Open AccessAssociation of Blood Donor Sex and Age With Outcomes in Very Low-Birth-Weight Infants Receiving Blood Transfusion
Author(s) -
Ravi M. Patel,
Joshua Lukemire,
Neeta Shenvi,
Connie M. Arthur,
Sean R. Stowell,
Martha SolaVisner,
Kirk A. Easley,
John D. Roback,
Ying Guo,
Cassandra D. Josephson
Publication year - 2021
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2021.23942
Subject(s) - medicine , retinopathy of prematurity , bronchopulmonary dysplasia , birth weight , gestational age , pediatrics , blood transfusion , poisson regression , necrotizing enterocolitis , low birth weight , incidence (geometry) , pregnancy , surgery , population , physics , environmental health , optics , biology , genetics
Key Points Question Is the sex or age of a blood donor associated with morbidity or mortality in very low-birth-weight infants receiving blood transfusion? Findings In this cohort study of 181 very low-birth-weight infants at 3 centers, infants receiving red blood cell transfusion from female donors had a lower risk of death or serious morbidity compared with those who received transfusion from male donors. The protective association between female donor and adverse outcomes increased with increasing donor age, but diminished with increasing number of blood transfusions. Meaning These findings suggest that characteristics of blood donors, such as sex and age, may be associated with recipient outcomes in very-low-birth weight infants receiving blood transfusions.
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