Detection of TP53 Clonal Variants in Papanicolaou Test Samples Collected up to 6 Years Prior to High-Grade Serous Epithelial Ovarian Cancer Diagnosis | Zendy

Lara Paracchini | Zendy; Chiara Pesenti | Zendy; Martina Delle Marchette | Zendy; Luca Beltrame | Zendy; Tommaso Bianchi | Zendy; Tommaso Grassi | Zendy; Alessandro Buda | Zendy; Fabio Landoni | Zendy; Lorenzo Ceppi | Zendy; Cristina Bosetti | Zendy; Mariachiara Paderno | Zendy; Marco Adorni | Zendy; Debora Vicini | Zendy; Patrizia Perego | Zendy; Biagio Eugenio Leone | Zendy; Maurizio D’Incalci | Zendy; Sergio Marchini | Zendy; Robert Fruscio | Zendy

Open Access

Detection of TP53 Clonal Variants in Papanicolaou Test Samples Collected up to 6 Years Prior to High-Grade Serous Epithelial Ovarian Cancer Diagnosis

Author(s) -

Lara Paracchini,

Chiara Pesenti,

Martina Delle Marchette,

Luca Beltrame,

Tommaso Bianchi,

Tommaso Grassi,

Alessandro Buda,

Fabio Landoni,

Lorenzo Ceppi,

Cristina Bosetti,

Mariachiara Paderno,

Marco Adorni,

Debora Vicini,

Patrizia Perego,

Biagio Eugenio Leone,

Maurizio D’Incalci,

Sergio Marchini,

Robert Fruscio

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.7566

Subject(s) - papanicolaou stain , interquartile range , medicine , serous fluid , cervical cancer , oncology , cancer , polymerase chain reaction , ovarian cancer , cohort , gynecology , pathology , biology , genetics , gene

Key Points Question Can clonal TP53 variants be detected in Papanicolaou tests performed several years before high-grade serous epithelial ovarian cancer (HGS-EOC) diagnosis? Findings This cohort study including 17 patients with HGS-EOC found that in 11 patients, tumor-specific TP53 variants were detected in Papanicolaou tests performed up to 6 years before the diagnosis of HGS-EOC. Meaning These findings suggest that very early diagnosis of HGS-EOC is potentially achievable and that further developments in highly sensitive molecular approaches could improve early diagnosis of HGS-EOC.

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