Bupropion for the Treatment of Apathy in Alzheimer Disease | Zendy

Franziska Maier | Zendy; Annika Spottke | Zendy; JanPhilipp Bach | Zendy; Claudia Bartels | Zendy; Katharina Büerger | Zendy; Richard Dodel | Zendy; Andreas Fellgiebel | Zendy; Klaus Fließbach | Zendy; Lutz Frölich | Zendy; Lucrezia Hausner | Zendy; Martin Hellmich | Zendy; Stefan Klöppel | Zendy; Arne Klostermann | Zendy; Johannes Kornhuber | Zendy; Christoph Laske | Zendy; Oliver Peters | Zendy; Josef Priller | Zendy; Tanja RichterSchmidinger | Zendy; Anja Schneider | Zendy; Kija ShahHosseini | Zendy; Stefan Teipel | Zendy; Christine A. F. Von Arnim | Zendy; Jens Wiltfang | Zendy; Frank Jessen | Zendy

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Bupropion for the Treatment of Apathy in Alzheimer Disease

Author(s) -

Franziska Maier,

Annika Spottke,

JanPhilipp Bach,

Claudia Bartels,

Katharina Büerger,

Richard Dodel,

Andreas Fellgiebel,

Klaus Fließbach,

Lutz Frölich,

Lucrezia Hausner,

Martin Hellmich,

Stefan Klöppel,

Arne Klostermann,

Johannes Kornhuber,

Christoph Laske,

Oliver Peters,

Josef Priller,

Tanja RichterSchmidinger,

Anja Schneider,

Kija ShahHosseini,

Stefan Teipel,

Christine A. F. Von Arnim,

Jens Wiltfang,

Frank Jessen

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.6027

Subject(s) - apathy , bupropion , medicine , placebo , dementia , mood , randomized controlled trial , quality of life (healthcare) , rivastigmine , alzheimer's disease , psychiatry , disease , donepezil , smoking cessation , alternative medicine , nursing , pathology

Key Points Question Is bupropion an effective and safe treatment for apathy in nondepressed patients with dementia of Alzheimer type? Findings In this 12-week, multicenter, double-blind, placebo-controlled, randomized clinical trial, 54 patients received bupropion and 54 received placebo. The mean change in the Apathy Evaluation Scale–Clinician Version score was not statistically significant between the treatment groups. Meaning Bupropion did not improve apathy in patients with dementia of Alzheimer type without depressed mood.

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