Association of Modifiable Lifestyle Factors With Cortical Amyloid Burden and Cerebral Glucose Metabolism in Older Adults With Mild Cognitive Impairment | Zendy

Noriyuki Kimura | Zendy; Yasuhiro Aso | Zendy; Kenichi Yabuuchi | Zendy; Masato Ishibashi | Zendy; Daiji Hori | Zendy; Yuuki Sasaki | Zendy; Atsuhito Nakamichi | Zendy; Souhei Uesugi | Zendy; Mika Jikumaru | Zendy; Kaori Sumi | Zendy; Atsuko Eguchi | Zendy; Hitoshi Obara | Zendy; Tatsuyuki Kakuma | Zendy; Etsuro Matsubara | Zendy

Open Access

Association of Modifiable Lifestyle Factors With Cortical Amyloid Burden and Cerebral Glucose Metabolism in Older Adults With Mild Cognitive Impairment

Author(s) -

Noriyuki Kimura,

Yasuhiro Aso,

Kenichi Yabuuchi,

Masato Ishibashi,

Daiji Hori,

Yuuki Sasaki,

Atsuhito Nakamichi,

Souhei Uesugi,

Mika Jikumaru,

Kaori Sumi,

Atsuko Eguchi,

Hitoshi Obara,

Tatsuyuki Kakuma,

Etsuro Matsubara

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.5719

Subject(s) - cognitive impairment , medicine , cognition , carbohydrate metabolism , amyloid (mycology) , cognitive decline , association (psychology) , dementia , risk factor , gerontology , neuroscience , psychology , psychiatry , disease , pathology , psychotherapist

Key Points Question Are modifiable lifestyle factors associated with cortical amyloid burden or cerebral glucose metabolism in older adults with mild cognitive impairment? Findings This cohort study included 118 older adults with mild cognitive impairment and found that total sleep time was associated with cerebral glucose metabolism after adjusting for covariates and false-discovery rate correction. Meaning In this study, the association of sleep duration with brain function was confirmed in older adults with mild cognitive impairment, thereby strengthening the potential of sleep as an evidence-based intervention for preventing cognitive impairment.

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