Association of Prenatal Exposure to Ambient Air Pollution With Circulating Histone Levels in Maternal Cord Blood | Zendy

Karen Vrijens | Zendy; Ann-Julie Trippas | Zendy; Wouter Lefebvre | Zendy; Charlotte Vanpoucke | Zendy; Joris Penders | Zendy; Bram G. Janssen | Zendy; Tim S. Nawrot | Zendy

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Association of Prenatal Exposure to Ambient Air Pollution With Circulating Histone Levels in Maternal Cord Blood

Author(s) -

Karen Vrijens,

Ann-Julie Trippas,

Wouter Lefebvre,

Charlotte Vanpoucke,

Joris Penders,

Bram G. Janssen,

Tim S. Nawrot

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.5156

Subject(s) - cord blood , histone h3 , medicine , pregnancy , obstetrics , epigenetics , biology , genetics , gene

Key Points Question Is prenatal exposure to ambient air pollution associated with levels of circulating total histone H3 and specific trimethylation marks in cord blood? Findings In this cohort study with 609 mother-newborn pairs, prenatal exposure to ambient air pollution was positively associated with circulating total histone H3 levels and with trimethylated histone H3 lysine 4 levels and negatively associated with trimethylated histone H3 lysine 36 levels. Meaning The findings of this study suggest that cord plasma histone H3 modifications during early life might indicate circulating histones are a risk factor in the development of air pollution–related disease later in life.

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