Association of Glycated Hemoglobin Levels With Risk of Pancreatic Cancer | Zendy

Bechien U. Wu | Zendy; Rebecca K. Butler | Zendy; Eva Lustigova | Zendy; Jean M. Lawrence | Zendy; Wansu Chen | Zendy

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Association of Glycated Hemoglobin Levels With Risk of Pancreatic Cancer

Author(s) -

Bechien U. Wu,

Rebecca K. Butler,

Eva Lustigova,

Jean M. Lawrence,

Wansu Chen

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.4945

Subject(s) - medicine , glycated hemoglobin , pancreatic cancer , cohort , interquartile range , diabetes mellitus , incidence (geometry) , cohort study , cancer registry , type 2 diabetes , cancer , endocrinology , physics , optics

Key Points Question What is the association of elevated glycated hemoglobin levels with the risk of pancreatic cancer? Findings In this cohort study with 851 402 participants, risk of pancreatic cancer varied in association with prior diabetes status as well as glycated hemoglobin level; however, this risk was not consistently observed across racial/ethnic groups. The number of patients who need to undergo further investigation to identify a single pancreatic cancer ranged from 206 to 600. Meaning In this study, the risk of pancreatic cancer associated with a newly identified elevation in blood glucose varied by race/ethnicity and did not reach a level sufficient to justify potential widespread screening.

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