Assessment of Sarcopenia Measures, Survival, and Disability in Older Adults Before and After Diagnosis With Cancer | Zendy

Grant R. Williams | Zendy; Yanjun Chen | Zendy; Kelly Kenzik | Zendy; Andrew M. McDonald | Zendy; Shlomit Strulov Shachar | Zendy; Heidi D. Klepin | Zendy; Stephen B. Kritchevsky | Zendy; Smita Bhatia | Zendy

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Assessment of Sarcopenia Measures, Survival, and Disability in Older Adults Before and After Diagnosis With Cancer

Author(s) -

Grant R. Williams,

Yanjun Chen,

Kelly Kenzik,

Andrew M. McDonald,

Shlomit Strulov Shachar,

Heidi D. Klepin,

Stephen B. Kritchevsky,

Smita Bhatia

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.4783

Subject(s) - sarcopenia , medicine , grip strength , lean body mass , cohort , cancer , population , gerontology , hand strength , physical therapy , cohort study , proportional hazards model , environmental health , body weight

Key Points Question What is the association of a cancer diagnosis with measures of sarcopenia? Findings In this matched cohort study of 515 older patients who developed cancer from the Health, Aging, and Body Composition (Health ABC) study, a steeper decline in gait speed prior to a cancer diagnosis and accelerated declines in appendicular lean mass after a cancer diagnosis were found, which were most striking in patients with metastatic disease. Meaning Accelerated losses in differing sarcopenia measures exist both prior to and after a cancer diagnosis and may present opportunities for targeted interventions to improve outcomes.

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