Effect of Zinc Supplementation vs Placebo on Mortality Risk and HIV Disease Progression Among HIV-Positive Adults With Heavy Alcohol Use | Zendy

Matthew S. Freiberg | Zendy; Debbie M. Cheng | Zendy; Natalia Gnatienko | Zendy; Elena Blokhina | Zendy; S. M. Coleman | Zendy; Margaret F. Doyle | Zendy; T. V. Yaroslavtseva | Zendy; Carly Bridden | Zendy; Kaku SoArmah | Zendy; Russell P. Tracy | Zendy; Kendall Bryant | Zendy; Dmitry Lioznov | Zendy; Evgeny Krupitsky | Zendy; Jeffrey H. Samet | Zendy

Open Access

Effect of Zinc Supplementation vs Placebo on Mortality Risk and HIV Disease Progression Among HIV-Positive Adults With Heavy Alcohol Use

Author(s) -

Matthew S. Freiberg,

Debbie M. Cheng,

Natalia Gnatienko,

Elena Blokhina,

S. M. Coleman,

Margaret F. Doyle,

T. V. Yaroslavtseva,

Carly Bridden,

Kaku SoArmah,

Russell P. Tracy,

Kendall Bryant,

Dmitry Lioznov,

Evgeny Krupitsky,

Jeffrey H. Samet

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.4330

Subject(s) - medicine , placebo , cohort , cohort study , pathology , alternative medicine

Key Points Question Does zinc supplementation reduce mortality and cardiovascular disease risk, reduce levels of inflammation and microbial translocation, and slow HIV disease progression among people with heavy alcohol use who are living with HIV/AIDS? Findings In this randomized clinical trial that included 254 participants, zinc supplementation did not change the Veterans Aging Cohort Study Index score, a surrogate marker for total mortality, or other outcomes at 18 months. Meaning Zinc supplementation did not decrease mortality risk in people with heavy alcohol use who are living with HIV/AIDS.

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