Open AccessAssessment of Treatment Strategies to Achieve Hepatitis C Elimination in Canada Using a Validated Model
Author(s) -
Mawuena Binka,
Naveed Z. Janjua,
Jason Grebely,
Chris Estes,
Dena L. Schanzer,
Jisoo A. Kwon,
Naglaa H. Shoukry,
Jeffrey C. Kwong,
Homie Razavi,
Jordan J. Feld,
Mel Krajden
Publication year - 2020
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2020.4192
Subject(s) - medicine , hepatitis c , hepatitis c virus , epidemiology , antiviral treatment , harm reduction , environmental health , chronic hepatitis , family medicine , immunology , virus , human immunodeficiency virus (hiv)
Key Points Question What strategies are needed to meet the goal of hepatitis C virus elimination in Canada by 2030? Findings In this decision analytical model, the sustained annual treatment of 10 200 individuals with hepatitis C virus infection was associated with a 5-fold reduction in chronic hepatitis C virus infections and a substantial decrease in liver-associated morbidity and mortality, and the achievement of hepatitis C elimination in Canada by 2030. However, this model indicates that a rapid decrease in the initiation of hepatitis C virus treatment would preclude Canada from achieving this goal. Meaning Results of this study suggest that hepatitis C virus elimination may be achievable in Canada by 2030 if current national hepatitis C virus treatment rates are sustained during the next decade.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom