Open AccessDevelopmental Outcomes Among Young Children With Congenital Zika Syndrome in Brazil
Author(s) -
Anne Wheeler,
Danielle Toth,
Ty A. Ridenour,
Lucélia Nóbrega,
Raíne Borba Firmino,
Cláudia Marques da Silva,
Pollyanna Carvalho,
Douglas José Marques,
Katherine C. Okoniewski,
Liana O. Ventura,
Donald B. Bailey,
Camila V. Ventura
Publication year - 2020
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2020.4096
Subject(s) - toddler , zika virus , bayley scales of infant development , medicine , pediatrics , intellectual disability , developmental milestone , rehabilitation , child development , early childhood , psychology , developmental psychology , cognition , psychiatry , physical therapy , psychomotor learning , virus , virology
Key Points Question What are the observed neurodevelopmental sequelae among young children with congenital Zika syndrome (CZS) identified during the Zika virus outbreak in Brazil from 2015 to 2016? Findings In this case series of 121 young children, nearly all children with CZS demonstrated profound developmental delays at age 2 to 3 years across all domains of functioning, with a relative strength in receptive communication. Severity of microcephaly at birth was the only significant factor associated with the severity of delays. Meaning In this study, most children diagnosed with CZS had profound developmental delays; however, there was variability within their developmental profile, providing direction for intervention.
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